Cancer epigenetics: Moving forward

Moving Forward in Human Cancer Risk Assessment

BACKGROUND The current safety paradigm for assessing carcinogenic properties of drugs, cosmetics, industrial chemicals, and environmental exposures relies mainly on in vitro genotoxicity testing followed by 2-year rodent bioassays. This testing battery is extremely sensitive but has low specificity. Furthermore, rodent bioassays are associated with high costs, high animal burden, and limited pr...

Moving forward in HIV-associated cancer.

Cancer has been linked to HIV since the earliest days of the epidemic. The unusually frequent occurrence of Kaposi sarcoma (KS) among men who have sex with men (MSM) in 1981 was a sentinel observation leading to the inclusion of KS in the first AIDS case definition. More than three decades later, major research investments have led to striking advances in understanding HIV pathogenesis, with an...

Stem cell epigenetics: looking forward.

The integrity of tissues is maintained by adult stem cells during adulthood. However, recent work indicates that tissues often contain more than one population of stem cells that are located at distinct niches and display different behaviors, making the role of stem cells in tissue homeostasis far more complex than previously thought. Generally, each population of stem cells predominantly contr...

Moving Forward

.......Having reached the end of my second term as editor in chief, the time has come for Micro to move forward to the next phase of its evolution. I am delighted to announce that Dr. Erik Altman from IBM Research is the new Micro EIC. Erik is an accomplished and highly respected industry architect and researcher who has held numerous leadership positions within the computing community. He has ...

Moving forward.